门脉性肝硬化典型的病理变化是( )

A.肝细胞变性坏死
B.结缔组织增生
C.正常肝小叶结构破坏
D.肝内血管网改建
E.再生结节及假小叶形成

参考答案：E

门脉性肝硬化的病理改变为由广泛增生的纤维组织将肝小叶分割、包绕成大小不等、圆形或椭圆形肝细胞团，称为假小叶。选项E正确。其他四个选项虽然也会在肝硬化的病理改变中出现，但不是肝硬化的特征性改变。

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